HELLP Syndrome
نویسندگان
چکیده
HELLP syndrome is a multisystemic disorder with an incidence of 0.17-0.85% of all pregnancies. Its etiopathogenesis is not completely understood. The most widely accepted hypotheses are: a change in the immune feto-maternal balance, platelet aggregation, endothelial dysfunction, arterial hypertension and an inborn error of the fatty acid oxidative metabolism. Hepatic involvement occurs by intravascular fibrin deposition and hypovolemia. Maternofetal complications cause a 6.7-70% perinatal mortality rate and a 1-24% maternal mortality rate. The recognition of HELLP syndrome and the rapid initiation of therapy are required for the improvement of materno-fetal prognosis.
منابع مشابه
Early preeclampsia and HELLP syndrome in a 20 week pregnant patient
The first time Weinstein in 1982 described patients with the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP) in pregnant preeclamptic and eclamptic patients. This syndrome is a severe form of preeclampsia or eclampsia. Usually HELLP syndrome occurs at the third trimester and only 15% occur before the 27th week of pregnancy and rarely before the 20th week of pregna...
متن کاملPlasmapheresis: Lifesaving treatment in severe cases of HELLP syndrome
Abstract Background: HELLP syndrome is an important complications in pregnancy which increases maternal and fetal mortality. This disease usually remits with supportive treatment which includes prescription of corticosteroid, magnesium sulfate, stabilization of mother and pregnancy termination. Plasmapheresis is a treatment of choice which improves clinical outcomes in complicated cases....
متن کاملHyperreactio Luteinalis with early-onset HELLP syndrome: A case report
Introduction: Hyperreactio Luteinalis (HL) is a rare benign condition in pregnancy which is characterized by bilaterally multicystic ovarian enlargement containing theca lutein cysts caused by increased production of hCG. HL is mostly associated with hydatidiform mole and multiple pregnancies. Correspondence: Azin Alavi, ...
متن کاملHELLP syndrome. Women with partial HELLP syndrome (PHS) should be studied and managed separately from women with HELLP syndrome or severe preeclampsia. The incidence of HELLP syndrome
Hemolysis, elevated liver enzymes and low platelet count are alterations in laboratory tests that are found in pregnant or post-delivery women who have preeclampsia. The term HELLP syndrome was coined for this set of alterations by Weinstein in 1982. Since then many reports have been presented, but the quantification of laboratory tests has differed among them. Since Sibai proposed strict crite...
متن کاملAtypical HELLP Syndrome in a Hydatidiform Molar Pregnancy: A Case Report
HELLP syndrome is a serious complication in pregnancy characterized by hemolysis, elevated liver enzymes and low platelet count [1]. First named by Weinstein in 1982, HELLP syndrome is a very serious manifestation of elevated blood pressure and proteinuria in pregnancy. Among pregnant women in the United States, approximately 5-8% will develop preeclampsia. Of those women, 15% will develop HELL...
متن کاملGenetic Aspects of Preeclampsia and the HELLP Syndrome
Both preeclampsia and the HELLP syndrome have their origin in the placenta. The aim of this study is to review genetic factors involved in development of preeclampsia and the HELLP syndrome using literature search in PubMed. A familial cohort links chromosomes 2q, 5q, and 13q to preeclampsia. The chromosome 12q is coupled with the HELLP syndrome. The STOX1 gene, the ERAP1 and 2 genes, the syncy...
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تاریخ انتشار 2007